Preoperative Magnetic Resonance Imaging FeaturesAssociated with Positive Resection Margins in Patientswith Invasive Lobular Carcinoma

Objective@#To investigate preoperative magnetic resonance imaging (MRI) findings associated with resection margin statusin patients with invasive lobular carcinoma (ILC) who underwent breast-conserving surgery. @*Materials and Methods@#One hundred and one patients with ILC who underwent preoperative MRI were included. MRI(tumor size, multifocality, type of enhancing lesion, distribution of non-mass enhancement [NME], and degree of backgroundparenchymal enhancement) and clinicopathological features (age, pathologic tumor size, presence of ductal carcinoma in situ[DCIS] or lobular carcinoma in situ, presence of lymph node metastases, and estrogen receptor/progesterone receptor/humanepidermal growth factor receptor type 2 status) were analyzed. A positive resection margin was defined as the presence ofinvasive cancer or DCIS at the inked surface. Logistic regression analysis was performed to determine pre- and postoperativevariables associated with positive resection margins. @*Results@#Among the 101 patients, 21 (20.8%) showed positive resection margins. In the univariable analysis, NME,multifocality, axillary lymph node metastasis, and pathologic tumor size were associated with positive resection margins.With respect to preoperative MRI findings, multifocality (odds ratio [OR] = 3.977, p = 0.009) and NME (OR = 2.741, p = 0.063)were associated with positive resection margins in the multivariable analysis, although NME showed borderline significance. @*Conclusion@#In patients with ILC, multifocality and the presence of NME on preoperative breast MRI were associated withpositive resection margins.

Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

BACKGROUND AND OBJECTIVES: The present study investigated the association between preoperative neutrophil-to-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). MATERIALS AND METHODS: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis. RESULTS: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence. CONCLUSION: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.